|
KMID : 1033620230500010034
|
|
Clinical and Experimental Reproductive Medicine
2023 Volume.50 No. 1 p.34 ~ p.43
|
|
|
Identification of royal jelly as a potential new drug to protect the ovarian reserve and uterus against cyclophosphamide in rats
|
|
Mehmet Bulbul
Ali Tekce
Ebru Annac
Omer Korkmaz
Muhittin Onderci
Deniz Korkmaz
Akin Mustafa Demirci
|
|
|
Abstract
|
|
|
Objective : The aim of this study was to investigate the effect of royal jelly (RJ), a powerful natural antioxidant, on cyclophosphamide-induced ovarian damage.
Methods : Thirty-two Wistar albino rats were divided into four groups. Oral treatment was administered to all rats for 16 days after a single intraperitoneal injection. The control group received intraperitoneal and oral saline; the RJ group received intraperitoneal saline and 100 mg/kg/day oral RJ; the cyclophosphamide group received intraperitoneal 100 mg/kg cyclophosphamide and oral saline; and the treatment group received intraperitoneal 100 mg/kg cyclophosphamide and 100 mg/kg/day oral RJ. The groups were compared in terms of ovarian reserve tests and histopathological changes in the ovary and uterus.
Results : All follicle counts were higher in the treatment group than in the cyclophosphamide group. The increase in the number of preantral follicles (p=0.001) and the decrease in the number of atretic follicles (p=0.004) were statistically significant. RJ treatment significantly improved follicular degeneration and cortical fibrosis in the ovary and epithelial and gland degeneration in the uterus due to cyclophosphamide toxicity.
Conclusion : According to these results, RJ reduces cyclophosphamide-related ovarian and endometrial damage in rats. For this reason, it should be further investigated to determine its effects on reproductive function.
|
|
|
KEYWORD
|
|
|
Cyclophosphamide, Ovarian follicle, Ovarian reserve, Royal jelly
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|